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The final proposed mechanism of RBC vasodilation while in the existence of nitrite would be the reduction of nitrite to NO by Hb. Brooks first researched the nitrite Hb conversation in 1937 which function was later on prolonged by Doyle in 1981 (Brooks, 1937; Doyle et al., 1981). Nitrite reacts with deoxygenated Hb to form metHb and NO (Brooks, 193